Sublingual misoprostol versus oral and vaginal misoprostol in
inducing mid-trimester medical abortion
Department of Obstetrics and Gynaecology, University ‘V.Goldis’
Arad, Romania Clinic Hospital of Obstetrics and Gynaecology, ‘Salvator Vuia’
Introduction: The new route of sublingual administration
of misoprostol was used by 34 -women requesting mid-trimester termination of
pregnancy because of various medical reasons. The efficiency and acceptability
of this regimen were studied versus those obtained by the use of oral and
Aims and Methods: The women were given 200 microg.
misoprostol sublingually followed by 100 microg. every 1h until delivery. The
abortion rate and the median induction-to-abortion interval were compared with
those obtained by using oral misoprostol (200 microg. every 1h until delivery),
vaginal misoprostol (200 microg.), endocervico-vaginally administrated
misoprostol (200 microg.vaginally and 200 microg.endocervically).
Results: The overall abortion rate was 100% within 24h
and the median induction-to-abortion interval was 10,5h (range 7– 16,5). The
side effects were represented by pelvic pain and in a few cases by fever and
chills. Comparing these results with those obtained by oral, vaginal and
endocervico-vaginally administrated misoprostol we can observe a greater rate of
abortion within 24h and a smaller median induction-to abortion interval in the
sublingually regimen. The acceptability of the sublingually administrated
misoprostol was good, 96,5%of the women would choose this method again because
it is convenient to take, it avoids the painful vaginal administration and gives
more privacy during the abortion process.
Conclusions: This regimen of sublingual misoprostol is an
effective and acceptable method of medical mid-trimester abortion.