Yasmin® and the extended regimen: current experience 

Yasmin® and the extended regimen: current experience 

M. Sillem 

Department of

Obstetrics and Gynecology, Neuwied Red Cross Academic Hospital, Germany 


conventional regimen for hormonal oral contraceptives is a 21-day pill-taking

period followed by a 7-day pill-free interval. In a recent survey among 252 oral

contraceptive users in five European countries, women were asked if they were

aware of the possibility of postponing menstruation by delaying pill intake and

whether they had used this method. Overall, 32% had delayed menstruation at some

time, and 37% were aware of the method but had not used it. Of the 79 women who

had postponed menstruation, almost two-thirds had seldom done so, while 11% used

the method more than once every 3 months. The majority of these women had

delayed their menstruation for a period ranging from 1 week to 3 months. In the

total population surveyed, 46% were very or somewhat interested in trying the

concept of postponement. 

In a large, prospective, observational 6-month study in

Germany, cycle control, premenstrual symptoms and general well-being were

compared in 1433 women taking the oral contraceptive Yasmin®, containing 30 µg

ethinylestradiol and 3 mg drospirenone, in either an extended regimen (63–126

days) or a conventional regimen (short cycle). Fluid retention was reduced in

49% of women on the extended regimen compared to 34% of women on the

conventional regimen. Women reported a reduction in breast tenderness of 50% on

the extended regimen and 40% on the short-cycle regimen, while one-third of the

women on either regimen noticed an improvement in their skin condition.

Improvement in dysmenorrhea was reported by 65% and 50% of women on the extended

and short regimens, respectively. General well-being was improved in 85% on the

extended regimen and 66% on the short-cycle regimen (p<0.0001). Altogether, 97% of extended-cycle users and 91% of short-cycle users would recommend Yasmin® for further treatment. These results confirm previous observations that Yasmin® reduces premenstrual symptoms and improves general well-being. These effects were further increased through application of an extended cycle regimen.

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