Evaluation of the pregnancy rate, hyperlipidemia, hyperglycemia
and abnormal bleeding in progesteron only pill (POP) users during breastfeeding
Maryam Kashanian and Mohsen Fekrat
Iran University of Medical Sciences, Tehran,
Objective Evaluation of the pregnancy rate (including ectopic
hyperlipidemia, hyperglycemia and abnormal bleeding in progesteron only pill
(POP) users during breastfeeding.
Method A semiexperimental study was performed
on 170 women, who were 20-45 years old during breastfeeding.They used
Lynestrenol for contraception,which had been started two months after delivery
and had been continued for six months.Fasting blood sugar(FBS),cholestrol,triglyceride(TG),
HDL-C,LDL-C,was measured at the beginning of lynestrenol use and again 3 and 6
months later.Then these amounts were compared.Pregnancy rate ,ectopic pregnancy(EP)
rate and abnormal bleeding was recorded during the period of POP use.
Among 170 women, only one pregnancy occurred(0.58%).There was no EP.FBS,cholestrol,triglyceride,HDL-C,LDL-C
did not have any clinically significant changes.(FBS=65.3±mg/dl before and
88±6.1mg/dl after drug use,p<0.001 but the amounts after treatment, were in the normal range,cholestrol=161.5±20.2 mg/dl before and 169±10.5 mg/dl after drug use,p<0.001 and again amounts after treatment were in the normal range,TG=73.7±8.7 and 76.4±7.1mg/dl before and after drug use, respectively,without a statistically significant difference,LDL-C=108±10.2 and 111±8.5mg/dl,and HDL-C=41.4±3.5 and 39.1±4.2mg/dl before and after treatment respectively without a statistically significant difference.Menorrhagia was the only important complication which was observed in 34.7% of patients and began during the first month of treatment and reduced gragually over time.
Regarding to the little effects of POPs on lipid profile and blood sugar,it can
be offered as an effective method for contraception in patients who are at risk
for cardiovascular disease and also diabetics and in women who can not use
combined pills,and in women older than 40 years old ,who their ovarian function
has been, because in this group of patients ,unwanted estrogen effects are